2025 Audi S5 vs 2025 Mercedes-Benz E-Class

$57,900 · Hatchback

$62,450 · Sedan

Comparison Overview

Choosing between the nimble 2025 Audi S5 Hatchback and the refined 2025 Mercedes-Benz E-Class Sedan is tough, especially when comparing pure performance against practicality. The core dilemma boils down to whether you prioritize driving excitement or long-term efficiency and space. The Audi S5 packs a significant punch with 349 hp and 369 lb-ft of torque, making its 20 City MPG a reasonable trade-off for accessible, brisk performance starting at an MSRP of $57,900. Conversely, the E-Class commands a $4,550 higher entry price at $62,450 and relies on 255 hp, but it rewards daily driving with a better combined MPG of 28. Furthermore, the S5’s hatchback body grants it a substantially larger 21.8 cu ft of cargo space compared to the E-Class Sedan’s 12.7 cu ft, tilting the scales toward versatility for the Audi.

Size Comparison

Performance

Fuel Efficiency

Full Specifications

Our Verdicts

🚗 Best for Commuters

2025 Mercedes-Benz E-Class

The Mercedes-Benz E-Class offers better fuel economy with 28 combined MPG versus the Audi S5's 23, reducing weekly running costs.

👨‍👩‍👧‍👦 Best for Families

2025 Audi S5

The Audi S5 hatchback provides significantly more utility with 21.8 cu ft of cargo space, easily accommodating more family gear than the E-Class Sedan's 12.7 cu ft.

🏎️ Best for Enthusiasts

2025 Audi S5

The Audi S5 delivers significantly more performance hardware with 349 hp and 369 lb-ft of torque compared to the E-Class's 255 hp.

💰 Best Value

2025 Audi S5

The Audi S5 costs $4,550 less while offering substantially more power and superior cargo capacity.

Choose the Audi S5 if...

You crave spirited driving, thanks to the S5's 349 hp and 369 lb-ft torque figures.
You need maximum utility from a compact luxury vehicle, as the Hatchback offers 21.8 cu ft of cargo room.
You prefer saving $4,550 upfront, given the S5's lower $57,900 MSRP.

Choose the Mercedes-Benz E-Class if...

Fuel efficiency is paramount, as the E-Class achieves 5 MPG better combined (28 MPG) than the S5.
You prefer the size and stature of a traditional sedan body, as the E-Class is over 7 inches longer.
You want the smoother, more traditional luxury experience associated with a rear-wheel-drive setup and a 9-speed automatic.

Key Dimensions

Dimension	Audi S5	Mercedes-Benz E-Class
Length	187.2"	194.9"
Width	72.6"	74.0"
Height	54.6"	57.9"
Wheelbase	111.2"	116.6"

Features Comparison

Safety

Feature	Audi	Mercedes-Benz
Lane Departure Warning	✓	—
Lane Keeping Assist System	✓	—
Pre-Collision Safety System	✓	✓
Post-Collision Safety System	✓	✓
Dual Front Side-Mounted Airbags	✓	✓
Front Head Airbags	✓	✓
Rear Head Airbags	✓	✓
Passenger Airbag Occupant Sensing Deactivation	✓	✓
Electronic Stability Control	✓	✓
Traction Control System	✓	✓
LATCH System	✓	✓
Rear Door Child Safety Locks	✓	✓
Anti-lock Brakes (ABS)	4-Wheel	4-Wheel
Front Ventilated Disc Brakes	✓	✓
Rear Ventilated Disc Brakes	✓	✓
Brake Preparation System	✓	✓
Brake Assist	✓	✓
Tire Pressure Monitoring System	✓	✓
Automatic Headlights	✓	✓
Headlight Delay-Off	✓	✓
LED Headlights	✓	✓
Daytime Running Lights	✓	✓
Integrated Turn Signal Mirrors	✓	✓
Front Headrests	2	2
Front Integrated Headrests	✓	—
Rear Headrests	3	3
Rear Height Adjustable Headrests	✓	✓
Rear Center 3-Point Seatbelt	✓	✓
Engine Immobilizer	✓	✓
Blind Spot Monitor	—	✓
Driver Attention Alert	—	✓
Brake Drying	—	✓
Adaptive Headlights	—	✓
Front Power Adjustable Headrests	—	✓
Anti-Theft Alarm System (Remote)	—	✓

Engine

Feature	Audi	Mercedes-Benz
Base Engine Displacement	3.0 L	2.0 L
Number of Cylinders	V6	inline 4
Base Engine Type	gas	mild hybrid
Horsepower	349 hp @ 6300 rpm	255 hp @ 5800 rpm
Torque	369 lb-ft @ 3200 rpm	295 lb-ft @ 2000 rpm
Number of Valves	24	16
Camshaft Type	Double overhead cam (DOHC)	Double overhead cam (DOHC)
Variable Valve Timing	Variable	Variable
Fuel Injection Type	✓	✓

Drive Train

Feature	Audi	Mercedes-Benz
Transmission Type	8-speed shiftable automatic	9-speed shiftable automatic
Drivetrain Type	all wheel drive	rear wheel drive
Center Differential Type	Limited Slip	—

Fuel

Feature	Audi	Mercedes-Benz
Fuel Type	premium unleaded (recommended)	premium unleaded (required)
EPA Fuel Economy (City/Highway)	20/29 MPG	25/33 MPG
EPA Fuel Economy (Combined)	23 MPG	28 MPG
EPA Driving Range (City/Highway)	306.0/443.7 mi.	435.0/574.2 mi.
Fuel Tank Capacity	15.3 gal.	17.4 gal.

Comfort & Convenience

Feature	Audi	Mercedes-Benz
Push Button Start	✓	✓
Tilt and Telescopic Steering Wheel	✓	—
Transmission Controls on Steering Wheel	✓	✓
Audio Controls on Steering Wheel	✓	✓
Electric Power Steering	✓	✓
Rear View Camera	✓	✓
Front Parking Sensors	✓	✓
Rear Parking Sensors	✓	✓
Adaptive Cruise Control	✓	—
Universal Remote Transmitter	✓	✓
Front Cupholders	✓	✓
Rear Cupholders	✓	✓
Front Door Pockets	✓	✓
Rear Door Pockets	✓	✓
Front Seatback Storage	✓	✓
Leather Steering Wheel	✓	✓
Heated Steering Wheel	✓	—
Three Zone Climate Control	✓	—
Rear Ventilation Ducts with Fan Control	✓	—
Dual Vanity Mirrors	✓	✓
Auto-Dimming Rearview Mirror	✓	✓
Turn Signal Indicators in Mirrors	✓	✓
Cargo Floor Mats	✓	—
Power Tilt and Telescopic Steering Wheel	—	✓
Cruise Control on Steering Wheel	—	✓
Front View Camera	—	✓
Side View Camera	—	✓
Automatic Parking Assist	—	✓
Wireless Charging Pad	—	✓
Cruise Control	—	✓
Overhead Console with Storage	—	✓
Dual Zone Climate Control	—	✓
Rear Ventilation Ducts	—	✓
Interior Air Filtration	—	✓

In Car Entertainment

Feature	Audi	Mercedes-Benz
Infotainment Display	10.1 in	14.4 in
AM/FM Stereo	✓	✓
Premium Brand Speakers	Bang & Olufsen	—
Stereo Power	755W	—
Speaker System	19	6
Surround Audio	Discrete	—
Android Auto (Wired)	✓	—
Apple CarPlay (Wireless)	✓	✓
USB Port	✓	✓
Auxiliary Audio Input	✓	—
USB Port with External Media Control	✓	✓
Satellite Radio	✓	✓
Satellite Radio Trial Period	3 months	6 months
Speed Sensitive Volume Control	✓	—
Android Auto (Wireless)	—	✓

Power Feature

Feature	Audi	Mercedes-Benz
One-Touch Power Windows	4	4
Moonroof Type	1st Row Power Glass Extended	1st Row Power Glass Extended
Remote Keyless Entry	✓	—
Heated Mirrors	✓	✓
Keyless Entry	—	✓

Frontseats

Feature	Audi	Mercedes-Benz
Front Head Room	37.8 in.	37.3 in.
Front Leg Room	41.3 in.	41.5 in.
Front Shoulder Room	55.7 in.	57.8 in.
Seat Material: Leather/Sueded Microfiber	✓	—
Front Seat Type: Sport	✓	—
Driver Seat Power Adjustments	8-way	10-way
Driver Seat Height Adjustment	✓	✓
Driver Seat Lumbar Support	Power	Power
Passenger Seat Power Adjustments	8-way	10-way
Passenger Seat Height Adjustment	✓	✓
Passenger Seat Lumbar Support	Power	Power
Driver Seat Heating	Multi-level	Multi-level
Passenger Seat Heating	Multi-level	Multi-level
Seat Massage Function	✓	—
Seat Material: Leatherette	—	✓
Front Seat Type: Bucket	—	✓
Driver Seat Thigh Extension	—	✓
Driver Seat Memory Settings	—	3
Passenger Seat Thigh Extension	—	✓
Passenger Seat Memory Settings	—	3

Rearseats

Feature	Audi	Mercedes-Benz
Rear Head Room	37.0 in.	37.6 in.
Rear Leg Room	35.1 in.	36.2 in.
Rear Shoulder Room	54.5 in.	57.1 in.
Split-Folding Rear Seatback	✓	✓
Folding Center Armrest	✓	✓

Tires and Wheels

Feature	Audi	Mercedes-Benz
Wheel Finish	Painted Alloy	Painted Alloy
Wheel Diameter	19 in	—
Tire Type	Performance	—
Tire Size	✓	225/55R18
Spare Tire Type	Temporary	—
Spare Tire Location	Inside Mounted	—
Wheel Size	—	18 x 8.0 in
Run Flat Tires	—	✓

Suspension

Feature	Audi	Mercedes-Benz
Four-Wheel Independent Suspension	✓	✓
Front Stabilizer Bar	✓	✓
Rear Stabilizer Bar	✓	✓

Warranty

Feature	Audi	Mercedes-Benz
Basic Warranty	4 yr./ 50000 mi.	4 yr./ 50000 mi.
Drivetrain Warranty	4 yr./ 50000 mi.	4 yr./ 50000 mi.
Corrosion/Rust Warranty	12 yr./ unlimited mi.	4 yr./ 50000 mi.
Roadside Assistance	4 yr./ unlimited mi.	4 yr./ 50000 mi.
Hybrid Component Warranty	—	6 yr./ 62000 mi.

Frequently Asked Questions

Common questions about comparing the 2025 Audi S5 and 2025 Mercedes-Benz E-Class.

How much more fuel-efficient is the 2025 Mercedes-Benz E-Class than the Audi S5?

The E-Class sedan is notably more efficient, achieving 28 combined MPG compared to the S5's 23 combined MPG. This 5 MPG advantage translates to fewer stops at the premium unleaded pump for E-Class owners.

Is the 2025 Audi S5 fast enough to matter against the E-Class?

Yes, the S5 is significantly punchier, boasting 349 hp and 369 lb-ft of torque versus the E-Class’s 255 hp. This nearly 95 hp difference means the S5 will feel noticeably quicker during acceleration.

Which vehicle is better for hauling luggage or supplies?

The 2025 Audi S5 hatchback is the clear winner here, offering 21.8 cu ft of cargo volume. The E-Class Sedan is quite restricted, offering only 12.7 cu ft, making the S5 much more practical for large items.

What is the main cost difference between these two luxury vehicles?

The 2025 Mercedes-Benz E-Class has an MSRP that is $4,550 higher than the 2025 Audi S5; the E-Class starts at $62,450 while the S5 starts at $57,900.

Do both cars require premium fuel?

Yes, both vehicles require premium fuel for optimal performance. The Audi S5 lists premium as 'recommended,' while the Mercedes-Benz E-Class lists it as 'required.'

How do the driving dynamics differ based on drivetrain?

The Audi S5 comes standard with All-Wheel Drive (AWD) for enhanced traction in various conditions, while the Mercedes-Benz E-Class utilizes a traditional Rear Wheel Drive (RWD) setup.